Everything You Need to Know About CBD Cannabinoid

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Everything You Need to Know About CBD Cannabinoid

What are cannabinoids?

picture of cbd moleculeCannabinoids entail varying active compounds found in marijuana. These chemical elements therefore give the cannabis plant its recreational and medical properties. Out of a total of four hundred and eighty compounds present in this cannabis sativa plant, only sixty six are deemed to be or recognized as cannabinoids. There exist different types of cannabinoids such as THC and CBD which are received into the body through the cannabinoids receptors in the endocannabinoid system. This culminates into that feeling of getting high. CBD and THC are present in very high concentrations hence they are accorded the most recognition.

The levels and content of THC and CBD are different based on the varying plant. High strains of CBD cannabinoid are available but often marijuana contains a high content of THC than CBD.

Other classes of cannabinoids include;

  1. Cannabichromenes – CBC
  2. Cannabinodiol – CBDL
  3. Cannabinol – CBN
  4. Cannabigerols – CBG
  5. Cannabicyclol – CBL
  6. Cannabitriol – CBT
  7. Cannabielsoin – CBE

All these cannabinoids operate by interacting with distinct and specific receptors present on the cell surfaces.

This post simply aims to discuss and decipher the question, what is cbd cannabinoids?

CBD cannabinoids is an exogenous cannabinoid otherwise known as phytocannabinoid since it is produced outside the body and it is found in the cannabis plant simply known as marijuana.

CBD cannabinoid came to the limelight after it was used to quell and suppress an epileptic seizure live on national television.

CBD cannabinoid is available in a variety of forms. This ranges from oil, vaporizers, edibles and tinctures.

CBD is naturally present in high qualities in the cannabis plant hence it is very easily extracted from the plant in the form of oil. After the extraction, the CBD oil can be used to make capsules and other liquids or alternatively, it can be reduced into a crystalline form.

Cbd cannabinoid is much more renowned for its health benefits and not for its recreational purposes like THC. This is because the CBD cannabinoids does not have psychoactive effects since it does not bind and attach itself to the CB1 receptors in the brain. It therefore has no high and it is all about relaxation devoid of any intoxication.

There are several strains of high level cbd which have been bred and they are very potent as they contain 10-20% cbd cannabinoids.

 

How is CBD produced?

CBD cannabinoid can be produced in two different ways. The first one is in the cannabis plant where cannabigerolic acid is first synthesized by the plant. The plant then uses this compound to make cannabidiolic acid. The lapse of time plus the heat and light effects causes this cannabigerolic acid to decarboxylate hence this loss of carbon dioxide leaves the compound CBD.

The other mode is through synthetic production in the laboratory. However, this type of CBD is regulated and the possession of the same is illegal.

The body also naturally produces a CBD like molecule known as 2-Arachidonoylglycerol with the acronym (2-AG). It possesses similar neuromodulatory effects as CBD and it has been found in human breast milk.

CBD VS THC

Both of these cannabinoids interacts with receptors in different locations in the body. CBD does not bind on the receptors through the orthosteric site whereas THC binds and engages the cannabinoid on this orthosteric site. CBD therefore regulates this interaction by binding to a completely distinct and separate location.

That is what aids CBD to reduce the psychoactive effects of THC by completely reducing and suppressing them. People who feel unusually high after taking some cannabis coupled with other effects such as anxiety are usually victims of very much THC and very little CBD cannabinoid.

The CBD is usually able to modify and alter the body’s endocannabinoid ability to connect and interact with the primary binding site. This simple alteration often termed as the endocannabinoid tone is very influential in the treatment of various medical conditions.

What is the difference between the CBD cannabinoid levels in marijuana and hemp?

The main difference is the THC content present in these different varieties. Marijuana which is mostly used for recreational purposes contains high levels of THC while hemp only has small traces of THC.

The CBD cannabinoid found naturally in hemp is legal in the United States whereas the CBD from marijuana is federally illegal. However, several states have been legalizing it recently.

The strains of high level cbd cannabinoids include Harlequin, cannatonic and tsunami.

CBD cannabinoids is a very effective remedy in the reduction of the psychoactive effects that emanate from THC.

CBD cannabinoids is also fundamentally instrumental in the treatment of various psychological disorders such as schizophrenia, anxiety and depression.

It was documented on CNN that CBD cannabinoid is very useful in the treatment of certain forms of epilepsy in children such as dravet syndrome.

CBD cannabinoids also aids to ensure that the seizure frequency subsides and reduces massively for children who suffer from generalized seizures and other seizure disorders.

Cannabinoids cbd also aids to protect the brain from fatal damage due to its neuroprotective properties. It is therefore vital especially for people who are likely to suffer from brain damage after an injury.

Cannabinoid cbd also helps to significantly reduce pain in the body just like THC. It is also effective in the reduction of inflammation.

How does cannabinoid cbd work and what are its effects on the body?

The body has the endocannabinoid system which has receptors throughout the brain and the body. They are mostly concentrated in the central nervous system while others are located in different organs in the body. Some receptors can even be found in the reproductive organs, the skin and in the digestive tract.

CBD cannabinoid does not stimulate and bind itself to these receptors unlike THC which stimulates and activates the CB1 and CB2 receptors.

These cannabinoid receptors are involved in various bodily processes such as the memory, regulation of pain and moods and the human appetite.

The receptors can be stimulated and activated by CBD cannabinoids which are produced by the body namely endocannabinoid and by other plant cannabinoids which are outside the body such as cannabis and hemp.

It is therefore succinctly clear that cannabinoid cbd does not stimulate the CB1 and CB2 receptors but is stimulates the serotonin, adenosine and vanilloid receptors.

Cbd cannabinoids regulates the pain perception, temperature and inflammation by stimulating the TRPV-1 receptor.

The question that lingers therefore is, how does CBD cannabinoids reduce the psychoactive effects of THC?

CBD acts as the FAAH enzyme inhibitor. This is a compound which activates and stimulates the CB1 receptor hence when once inhibited, the activation of CB1 by THC is highly minimized by CBD thus ultimately reducing its psychoactive effects. CBD cannabinoid therefore has anti-psychoactive properties hence it reduces the euphoric effects that result from THC which is a psychoactive cannabinoid.

The anti-anxiety and anti-inflammatory effects and properties of cbd cannabinoids are manifest after the activation of the adenosine receptor by CBD.

The adenosine receptor stimulates the release of two neurotransmitters namely dopamine and glutamate and they play a very crucial role inside the body.

Specifically, dopamine is involved in reward mechanisms, motor control and cognition whereas glutamate is also involved in cognition as well, memory and learning. Glutamate also acts as a mediator of excitatory signals.

When CBD cannabinoid is in high concentration, it stimulates the 5-HT1A serotonin receptor thus ensuring that its antidepressant effects are manifest.

This serotonin receptor is also involved in other distinct processes such as pain perception, anxiety, appetite and anxiety.

CBD cannabinoid also inhibits GPR55 signaling hence minimizing cancer cell proliferation and bone reabsorption.

CBD cannabinoid is also beneficial as it acts as an analgesic, anti-tumoral agent and an anxiolytic. CBD is also polypharmacological and this means that it can affect several pathways in the body at the exact same time. This therefore makes it extremely difficult to study and make reasonable inferences on the same since it is virtually impossible to determine the effect that these different interactions have on each other. However, many patients who take medical cannabis find considerable relief after taking this cannabinoid.

All these benefits and positive purposes of cannabinoid CBD are not dependent on the presence of THC. CBD cannabinoid can therefore work unilaterally hence none psychoactive CBD can be utilized proving to be highly effective.

CBD and epilepsy

CBD will play a very pivotal role in the future treatment of epilepsy. A pharmaceutical company hailing from Britain known as GW pharmaceuticals tried a drug namely Epidiolex in its trials of the CBD medication. Epidiolex depicted very commendable results especially for patients who have Lennox-Gastaut syndrome and for the patients with Dravet syndrome as well. As highlighted earlier, CBD is highly neuroprotective as it works to ensure that the brain cells are healthy hence reducing brain cell damage. CBD therefore increases the effectiveness of the common anti-epileptic drugs to its neuroprotective properties.

CBD and schizophrenia

The CBD’s ability to reduce and curb the THC psychoactive properties is very helpful for schizophrenic patients. The hippocampus and prefrontal cortex are the two brain regions that are affected by THC. These brain regions are similarly implicated for patients who suffer from schizophrenia.

The opposite effects of CBD cannabinoid and THC in these brain regions have paved the way and opened a new window in the schizophrenic research.

Doctors highly recommend CBD cannabinoid due to its few side effects.

There exists a huge misconception that the CBD cannabinoid is psychoactive but this myth ought to be dispensed and invalidate forthwith.

CBD hemp oil

CBD can be readily found in CBD oil. This oil contains only minute traces of THC which as highlighted earlier is the main psychoactive cannabinoid.

The CBD oil therefore does not cause adverse psychoactive effects as it does not affect ones behavior, perception, consciousness and sensory awareness.

The CBD oil is derived from hemp which is a type of cannabis that contains only 0.3 percent THC. This is massively low even compared to the least potent marijuana.

CBD helps the endocannabinoid system by supporting the effects that the system brings about naturally.

This endocannabinoid system controls the homeostasis for varying bodily processes such as appetite, anxiety, pain and sleep. These body processes are affected by the outside environment thus the endocannabinoid system aids to sustain and keep them in balance thus curbing the fluctuation that the outside environment may cause.

The CBD cannabinoid supports all these effects that the endocannabinoid system seeks to restore and balance through constant modulation in order to ensure that the user functions at their best.

CBD oil has been tried to discover whether it has any adverse side effects. A daily dose of 300mg consumed for up to three months has been proven to be safe. A consumption of a higher daily dosage of up to 1200-1500 mg has also proven to be safe when consumed for up to four weeks.

Patients who suffer from various conditions especially chronic conditions such as epilepsy and cancer usually opt for medical cannabis oil obtained from different high CBD cannabis varieties.

A research looking into the side effects of the CBD cannabinoid has clearly depicted that it has no adverse effects on the following:

  1. pH levels
  2. Glucose levels
  3. Retching and vomiting
  4. Sodium and Potassium levels
  5. Heartbeat or pulse rate
  6. Body temperature
  7. Blood pressure

The inference is therefore that CBD cannabinoid has no adverse effects even when consumed at higher doses. However, the consumer of CBD oil should start with a lower dosage and increase to a higher dosage gradually in order to determine the dosage that works best for him.

CBD is therefore deemed safe for all family members and distinct demographics as it is not psychoactive and it is non-toxic as well.

Therefore, one ought to commence with a few drops daily until one is able to determine the best serving that is most suited for the individual’s endocannabinoid system.

The CBD cannabinoid is therefore growing to become a very popular cannabinoid that will benefit everyone as a wellness supplement due to its high nutritional properties.

The media has been on the forefront reporting about its benefits hence creating much more awareness about its very advantageous effects.

The CBD cannabinoid and all products containing the same can be found in marijuana stores and in varying online platforms and also health and wellness stores.

The market for CBD has been on the rise due to its numerous benefits thus many people like to use it as a daily supplement.

The CBD derived from marijuana is only available in specific states in the U.S hence people are looking for alternative sources due to surge and increased demand especially for medical marijuana for health and wellness purposes.

People therefore opt for hemp oil products as they are readily available in stores and other medical marijuana programs.

What does the future hold for CBD cannabinoid?

The future for Cannabinoid CBD is not as bleak as many pundits argued and posited a few years ago. Very many studies have clearly shown the many benefits that CBD has. There are many medical trials that continue to take place in a bid to try and demonstrate CBD’s efficacy in the treatment of varying medical conditions.

CBD cannabinoid has witnessed a huge surge in its inclusion in very many common products hence any doubts and remonstration towards this cannabinoid has vastly dissipated hence its continued international acclaim.

The cannabinoid CBD has received very many plaudits and platitudes and several countries especially in South America such as Paraguay. Brazil and Mexico have actually given approval for the use of CBD as a prescription medication. Many other countries have also allowed for its use as a dietary supplement.

The World Health Organization recently gave a recommendation and posited that CBD cannabinoid should not be scheduled as a drug. The recommendation will have a far reaching implication on how CBD cannabinoid is perceived worldwide and on the existing laws and policies surrounding the CBD in varying countries.

CONCLUSION

CBD is therefore a phytocannabinoid with so many benefits that are potentially lifesaving. It is therefore vital to debunk the myth that CBD cannabinoid is a bad strain that ought to be illegal. Many people often think that CBD can cause cognitive impairment but very many studies and anecdotal reports clearly prove that this is a false assumption.  Lawmakers should therefore not err in their conclusions about CBD as they make regulations and policies pertaining to the same. Various countries should therefore revisit their laws pertaining to CBD cannabinoid as its legalization could aid very many people to overcome various medical challenges that they are going through in different parts of the world. This is because the outdated laws have been against a plant that could be the biggest remedy for modern day diseases.

In the UK, the National Health Service (NHS) declared CBD as medicine. In the US, the cannabis products are listed as a schedule one drug under the United States Controlled Substances Act. The possession of the same therefore attracts a penalty and other legal implications since the law do not perceive CBD as a cannabinoid that has any medicinal value. The DEA still affirms that CBD is still illegal.

It is therefore imperative that countries commence to try and invest in much more research about the CBD cannabinoid before proceeding to implement a ban on the same. This is because all this CBD sanctions are not merited since very little research has been done by most countries to prove that cannabinoid CBD is actually harmful.

 

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